Odontogenic epithelial stem cells: Hidden sources

Sivan Padma Priya, Akon Higuchi, Salem Abu Fanas, Mok Pooi Ling, Vasantha Kumari Neela, P. M. Sunil, T. R. Saraswathi, Kadarkarai Murugan, Abdullah A. Alarfaj, Murugan A. Munusamy, Suresh Kumar

研究成果: 雜誌貢獻回顧評介論文同行評審

24 引文 斯高帕斯(Scopus)


The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed.

頁(從 - 到)1344-1352
期刊Laboratory Investigation
出版狀態已出版 - 1 12月 2015


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