Novel 3D coaxial flow-focusing nozzle device for the production of monodispersed collagen microspheres

Sravani Jaligama, Po Jung Huang, Jun Kameoka

研究成果: 書貢獻/報告類型會議論文篇章同行評審

3 引文 斯高帕斯(Scopus)

摘要

We have developed a 3D coaxial flow-focusing nozzle device for the mass production of monodispersed collagen microspheres and chemically crosslinked them using EDC (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide) and N-hydroxysuccinimide (NHS). The size of the microspheres was varied between 200 μm and 600 μm by adjusting the ratio of the flow rates of the dispersed and continuous phases. MDA231-GFP cells were attached to the surface of these particles and their viability was investigated. Because they are comprised of a natural biomaterial, these collagen microspheres will have numerous applications, including bone regeneration scaffolds for tissue engineering and analyses of cancer cell interactions in a 3D environment.

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主出版物標題2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
發行者Institute of Electrical and Electronics Engineers Inc.
頁面4220-4223
頁數4
ISBN(電子)9781457702204
DOIs
出版狀態已出版 - 13 10月 2016
事件38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
持續時間: 16 8月 201620 8月 2016

出版系列

名字Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
2016-October
ISSN(列印)1557-170X

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???event.eventtypes.event.conference???38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
國家/地區United States
城市Orlando
期間16/08/1620/08/16

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