Nanoparticle-enhanced ultrahigh-resolution surface plasmon resonance biosensors

F. C. Chien, S. J. Chen, W. P. Hu, G. Y. Lin, K. T. Huang

研究成果: 雜誌貢獻會議論文同行評審

1 引文 斯高帕斯(Scopus)


The present study proposes the use of a novel optical biosensor with Au nanoclusters embedded in a dielectric film to achieve a 10-fold improvement in the resolution performance. The proposed optical biosensor based on the attenuated total reflection (ATR) method excites both the surface plasmons (SPs) and particle plasmons (PPs) to enhance the local electro-magnetic field by controlling the size and volume fraction of the embedded Au nanoparticles to increase the resolution of the device. A co-sputtering method utilizing a multi-target sputtering system is used to fabricate the present dielectric films (SiO2) with embedded Au nanoclusters. It is shown that the sensitivity of the developed SPR biosensor can be improved by adjusting the size and volume fraction of the embedded Au nanoclusters in order to control the surface plasmon effect. The present gas detection and DNA hybridization experimental results confirm that the proposed Au nanocluster-enhanced SPR biosensor provides the potential to achieve an ultrahigh-resolution detection performance of approximately 0.1 pg/mm2 surface coverage of biomolecules.

頁(從 - 到)140-147
期刊Proceedings of SPIE - The International Society for Optical Engineering
出版狀態已出版 - 2004
事件Plasmonics in Biology and Medicine - San Jose, CA, United States
持續時間: 26 1月 200427 1月 2004


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