TY - JOUR
T1 - Multiscale entropy analysis of pulse wave velocity for assessing atherosclerosis in the aged and diabetic
AU - Wu, Hsien Tsai
AU - Hsu, Po Chun
AU - Lin, Cheng Feng
AU - Wang, Hou Jun
AU - Sun, Cheuk Kwan
AU - Liu, An Bang
AU - Lo, Men Tzung
AU - Tang, Chieh Ju
N1 - Funding Information:
Manuscript received March 21, 2011; revised May 13, 2011 and June 4, 2011; accepted June 8, 2011. Date of publication June 20, 2011; date of current version September 21, 2011. This work was supported in part by the National Science Council, Taiwan, under Grant NSC 99-2221-E-259-001. Asterisk indicates corresponding author. *H.-T. Wu is with the Department of Electrical Engineering, National Dong Hwa University, Hualien 97401, Taiwan (e-mail: [email protected]).
PY - 2011/10
Y1 - 2011/10
N2 - This study proposed a dynamic pulse wave velocity (PWV)-based biomedical parameter in assessing the degree of atherosclerosis for the aged and diabetic populations. Totally, 91 subjects were recruited from a single medical institution between July 2009 and October 2010. The subjects were divided into four groups: young healthy adults (Group 1, n 22), healthy upper middle-aged adults (Group 2, n 28), type 2 diabetics with satisfactory blood sugar control (Group 3, n 21), and unsatisfactory blood sugar control (Group 4, n 20). A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWV foot values within 30 min. The data, thus, obtained were analyzed with multiscale entropy (MSE). Large-scale MSE index (MEI LS) was chosen as the assessment parameter. Not only did MEI LS successfully differentiate between subjects in Groups 1 and 2, but it also showed a significant difference between Groups 3 and 4. Compared with the conventional parameter of PWV foot and MEI on R-R interval i.e., MEI (RRI) in evaluating the degree of atherosclerotic change, the dynamic parameter, MEI LS (PWV), could better reflect the impact of age and blood sugar control on the progression of atherosclerosis.
AB - This study proposed a dynamic pulse wave velocity (PWV)-based biomedical parameter in assessing the degree of atherosclerosis for the aged and diabetic populations. Totally, 91 subjects were recruited from a single medical institution between July 2009 and October 2010. The subjects were divided into four groups: young healthy adults (Group 1, n 22), healthy upper middle-aged adults (Group 2, n 28), type 2 diabetics with satisfactory blood sugar control (Group 3, n 21), and unsatisfactory blood sugar control (Group 4, n 20). A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWV foot values within 30 min. The data, thus, obtained were analyzed with multiscale entropy (MSE). Large-scale MSE index (MEI LS) was chosen as the assessment parameter. Not only did MEI LS successfully differentiate between subjects in Groups 1 and 2, but it also showed a significant difference between Groups 3 and 4. Compared with the conventional parameter of PWV foot and MEI on R-R interval i.e., MEI (RRI) in evaluating the degree of atherosclerotic change, the dynamic parameter, MEI LS (PWV), could better reflect the impact of age and blood sugar control on the progression of atherosclerosis.
KW - Atherosclerosis
KW - diabetic
KW - dynamic parameter
KW - multiscale entropy (MSE)
KW - pulse wave velocity (PWV)
UR - http://www.scopus.com/inward/record.url?scp=80053166674&partnerID=8YFLogxK
U2 - 10.1109/TBME.2011.2159975
DO - 10.1109/TBME.2011.2159975
M3 - 期刊論文
C2 - 21693413
AN - SCOPUS:80053166674
SN - 0018-9294
VL - 58
SP - 2978
EP - 2981
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10 PART 2
M1 - 5893923
ER -