Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

Jian Zhou; Heng Kwong Tsao; Yu Jane Sheng; Shaoyi Jiang

doi:10.1063/1.1757434

Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

Jian Zhou, Heng Kwong Tsao, Yu Jane Sheng, Shaoyi Jiang

化學工程與材料工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

116 引文斯高帕斯（Scopus）

摘要

The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.

原文	???core.languages.en_GB???
頁（從 - 到）	1050-1057
頁數	8
期刊	Journal of Chemical Physics
卷	121
發行號	2
DOIs	https://doi.org/10.1063/1.1757434
出版狀態	已出版 - 8 7月 2004

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10.1063/1.1757434

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AB - The adsorption and orientation of antibodies on different charged surfaces was analyzed using Monte Carlo simulations. Investigations show the effects of surface charge density, solution pH and ionic strength with different dipole moments. The orientation of the adsorbed antibody was found from the Van der Walls (VDW) and electrostatic interactions. The results show the ability to predict and control antibody orientation in the development of biosensors.

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Monte Carlo simulations of antibody adsorption and orientation on charged surfaces

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