Mineral substituted hydroxyapatite coatings deposited on nanoporous TiO2 modulate the directional growth and activity of osteoblastic cells†

Dharman Govindaraj, Mariappan Rajan, Murugan A. Munusamy, Akon Higuchi

研究成果: 雜誌貢獻期刊論文同行評審

19 引文 斯高帕斯(Scopus)

摘要

The biocompatibility of anodized titanium (TiO2) was improved by electrophoretically deposited mineral (strontium (Sr), magnesium (Mg) and zinc (Zn)) substituted hydroxyapatite (M-HAP). The M-HAP layer was grown on the anodized Ti surface at different deposition temperatures (room temperature, 60 and 80 C). The phases and morphologies of the M-HAP layers were influenced by the deposition temperature. The coatings were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Scanning electron microscopy equipped with energy dispersive X-ray analysis (SEM-EDX). Also, the effects of temperature and the mineral substitution of Sr, Mg and Zn for Ca on the physiochemical and biological properties of the M-HAP coatings were evaluated by the mechanical strength, ion dissolution and proliferation, alkaline phosphatase (ALP) activity and osteogenic expression of osteoblast like cells MG66 (HOS). Thus, the M-HAP deposition of TiO2 will serve as a potential candidate for orthopedic applications.

原文???core.languages.en_GB???
頁(從 - 到)58980-58988
頁數9
期刊RSC Advances
5
發行號73
DOIs
出版狀態已出版 - 2015

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