Microwave-assisted direct thioesterification of carboxylic acids

Yen Lin Chou, Yi Jhong, Sharada Prasanna Swain, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)

摘要

A one-pot synthesis of thioesters directly from carboxylic acids, N,N′-diphenylthiourea, triethylamine, and primary alkyl halides is described. Microwave-assisted heating and a catalytic amount of 4- (dimethylamino)pyridine (DMAP) further improved the yields. Both aromatic and aliphatic carboxylic acids were converted to the corresponding thioesters, and many functional groups were compatible with this reaction. Several possible reaction intermediates were investigated, and the quaternary ammonium salts, derived from alkyl halides and tertiary amines, were the intermediates to yield thioesters. A new reaction mechanism for this thioesterification is proposed.

原文???core.languages.en_GB???
頁(從 - 到)10201-10208
頁數8
期刊Journal of Organic Chemistry
82
發行號19
DOIs
出版狀態已出版 - 6 10月 2017

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