TY - JOUR
T1 - Microfluidic paper-based analytical devices for cancer diagnosis
AU - Shalaby, Ahmed A.
AU - Tsao, Chia Wen
AU - Ishida, Akihiko
AU - Maeki, Masatoshi
AU - Tokeshi, Manabu
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/3/15
Y1 - 2023/3/15
N2 - Cancer is a leading cause of death worldwide. Early diagnosis of cancer is crucial for successful treatment which, in turn, will decrease mortality. The development of low-cost, accurate, and easy to operate point-of-need (PON) devices to be used for cancer diagnosis and treatment follow-up is a worldwide need, especially in developing countries. Paper-based analytical devices (PADs) are considered a key solution, as they provide a low-cost platform for developing PON biosensors for cancer biomarker detections. There are various types of 2D and 3D PADs according to the type of paper substrate (filter paper, chromatographic paper, nitrocellulose membranes, etc.), fabrication method (wax printing, screen printing, cutting, etc.), detection technique used (colorimetry, fluorescence, chemiluminescence, electrochemiluminescence, electrochemical, etc.), the assay principle and recognition element used (antibodies, aptamers, DNA, nanoparticles, enzymes, etc.). Controlling all these factors determines the performance, accuracy, and sensitivity of the developed devices. This review discusses all these factors in the different PADs used for detection of cancer biomarkers and summarizes the advantages and disadvantages of each one.
AB - Cancer is a leading cause of death worldwide. Early diagnosis of cancer is crucial for successful treatment which, in turn, will decrease mortality. The development of low-cost, accurate, and easy to operate point-of-need (PON) devices to be used for cancer diagnosis and treatment follow-up is a worldwide need, especially in developing countries. Paper-based analytical devices (PADs) are considered a key solution, as they provide a low-cost platform for developing PON biosensors for cancer biomarker detections. There are various types of 2D and 3D PADs according to the type of paper substrate (filter paper, chromatographic paper, nitrocellulose membranes, etc.), fabrication method (wax printing, screen printing, cutting, etc.), detection technique used (colorimetry, fluorescence, chemiluminescence, electrochemiluminescence, electrochemical, etc.), the assay principle and recognition element used (antibodies, aptamers, DNA, nanoparticles, enzymes, etc.). Controlling all these factors determines the performance, accuracy, and sensitivity of the developed devices. This review discusses all these factors in the different PADs used for detection of cancer biomarkers and summarizes the advantages and disadvantages of each one.
KW - Biomarkers detection
KW - Cancer
KW - Microfluidic paper-based analytical devices (μPADs)
KW - PAD fabrication
KW - Paper-based sensors
KW - Point-of-need (PON)
UR - http://www.scopus.com/inward/record.url?scp=85145162970&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2022.133243
DO - 10.1016/j.snb.2022.133243
M3 - 期刊論文
AN - SCOPUS:85145162970
SN - 0925-4005
VL - 379
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
M1 - 133243
ER -