TY - JOUR
T1 - Micro-anatomical changes in major blood vessel caused by dengue virus (serotype 2) infection
AU - Priya, Sivan Padma
AU - Sakinah, S.
AU - Ling, Mok Pooi
AU - Chee, Hui Yee
AU - Higuchi, Akon
AU - Hamat, Rukman Awang
AU - Neela, Vasantha Kumari
AU - Alarfaj, Abdullah A.
AU - Munusamy, Murugan A.
AU - Hatamleh, Ashraf A.
AU - Al-Sabri, Ahmed E.
AU - Abdulaziz Al-Suwailem, Ibrahim Ahmad
AU - Rajan, Mariappan
AU - Benelli, Giovanni
AU - Marlina,
AU - Kumar, S. Suresh
N1 - Publisher Copyright:
© 2017
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Dengue virus (DENV) has emerged as a major economic concern in developing countries, with 2.5 billion people believed to be at risk. Vascular endothelial cells (ECs) lining the circulatory system from heart to end vessels perform crucial functions in the human body, by aiding gas exchange in lungs, gaseous, nutritional and its waste exchange in all tissues, including the blood brain barrier, filtration of fluid in the glomeruli, neutrophil recruitment, hormone trafficking, as well as maintenance of blood vessel tone and hemostasis. These functions can be deregulated during DENV infection. In this study, BALB/c mice infected with DENV serotype 2 were analyzed histologically for changes in major blood vessels in response to DENV infection. In the uninfected mouse model, blood vessels showed normal architecture with intact endothelial monolayer, tunica media, and tunica adventitia. In the infected mouse model, DENV distorted the endothelium lining and disturbed the smooth muscle, elastic laminae and their supporting tissues causing vascular structural disarrangement. This may explain the severe pathological illness in DENV-infected individuals. The overall DENV-induced damages on the endothelial and it's supporting tissues and the dysregulated immune reactions initiated by the host were discussed.
AB - Dengue virus (DENV) has emerged as a major economic concern in developing countries, with 2.5 billion people believed to be at risk. Vascular endothelial cells (ECs) lining the circulatory system from heart to end vessels perform crucial functions in the human body, by aiding gas exchange in lungs, gaseous, nutritional and its waste exchange in all tissues, including the blood brain barrier, filtration of fluid in the glomeruli, neutrophil recruitment, hormone trafficking, as well as maintenance of blood vessel tone and hemostasis. These functions can be deregulated during DENV infection. In this study, BALB/c mice infected with DENV serotype 2 were analyzed histologically for changes in major blood vessels in response to DENV infection. In the uninfected mouse model, blood vessels showed normal architecture with intact endothelial monolayer, tunica media, and tunica adventitia. In the infected mouse model, DENV distorted the endothelium lining and disturbed the smooth muscle, elastic laminae and their supporting tissues causing vascular structural disarrangement. This may explain the severe pathological illness in DENV-infected individuals. The overall DENV-induced damages on the endothelial and it's supporting tissues and the dysregulated immune reactions initiated by the host were discussed.
KW - Arbovirus
KW - BALB/c mice
KW - Dengue fever
KW - Hemorrhagic fever
KW - Vascular endothelial cells
UR - http://www.scopus.com/inward/record.url?scp=85017700550&partnerID=8YFLogxK
U2 - 10.1016/j.actatropica.2017.04.010
DO - 10.1016/j.actatropica.2017.04.010
M3 - 期刊論文
C2 - 28427958
AN - SCOPUS:85017700550
SN - 0001-706X
VL - 171
SP - 213
EP - 219
JO - Acta Tropica
JF - Acta Tropica
ER -