TY - JOUR
T1 - Measurement and modeling of metoclopramide hydrochloride (anti-emetic drug) solubility in supercritical carbon dioxide
AU - Sodeifian, Gholamhossein
AU - Hsieh, Chieh Ming
AU - Derakhsheshpour, Reza
AU - Chen, Yu Ming
AU - Razmimanesh, Fariba
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/7
Y1 - 2022/7
N2 - Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 × 10-5 to 5.56 × 10-5. To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated.
AB - Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 × 10-5 to 5.56 × 10-5. To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated.
KW - Metoclopramide hydrochloride
KW - Peng-Robinson equation of state
KW - Sodeifian model
KW - Solubility
KW - Supercritical carbon dioxide
UR - http://www.scopus.com/inward/record.url?scp=85128354287&partnerID=8YFLogxK
U2 - 10.1016/j.arabjc.2022.103876
DO - 10.1016/j.arabjc.2022.103876
M3 - 期刊論文
AN - SCOPUS:85128354287
SN - 1878-5352
VL - 15
JO - Arabian Journal of Chemistry
JF - Arabian Journal of Chemistry
IS - 7
M1 - 103876
ER -