Material Design for Next-Generation mRNA Vaccines Using Lipid Nanoparticles

Akon Higuchi, Tzu Cheng Sung, Ting Wang, Qing Dong Ling, S. Suresh Kumar, Shih Tien Hsu, Akihiro Umezawa

研究成果: 雜誌貢獻回顧評介論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

Vaccine development is among the critical issues for ceasing the COVID-19 pandemic. This review discusses the current usage of biomaterials in vaccine development and provides brief descriptions of the vaccine types and their working mechanisms. New types of vaccine platforms (next-generation vaccines and DNA- or mRNA-based vaccines) are discussed in detail. The mRNA vaccine encoding the spike protein viral antigen can be produced in a cell-free system, suggesting that mRNA vaccines are safer than “classic vaccines” using live or inactivated virus. The mRNA vaccine efficacy is typically high at approximately 95%. However, most mRNA vaccines need to be maintained at −20 or −70 degrees for storage for long periods (half a year) and their transportation because of mRNA vaccine instability in general, although mRNA vaccines with unmodified and self-amplifying RNA (ARCT-154, Arcturus), which have a lyophilized form, have recently been reported to be kept at room temperature. mRNA vaccines are typically entrapped in lipid nanoparticles composed of ionizable lipids, polyethylene glycol (PEG)-lipids, phospholipids, and cholesterol. These components and their composition affect mRNA vaccine stability and efficacy and the size of the mRNA vaccine. The development of an improved mRNA vaccine entrapped in sophisticated biomaterials, such as novel lipid nanoparticles, using new types of biopolymers or lipids is necessary for high efficacy, safe transportation and long-term storage of the next generation of mRNA vaccines under mild conditions.

原文???core.languages.en_GB???
期刊Polymer Reviews
DOIs
出版狀態已被接受 - 2022

指紋

深入研究「Material Design for Next-Generation mRNA Vaccines Using Lipid Nanoparticles」主題。共同形成了獨特的指紋。

引用此