TY - JOUR
T1 - Looking into dental pulp stem cells in the therapy of photoreceptors and retinal degenerative disorders
AU - Alsaeedi, Hiba Amer
AU - Lam, Chenshen
AU - Koh, Avin Ee Hwan
AU - Teh, Seoh Wei
AU - Mok, Pooi Ling
AU - Higuchi, Akon
AU - Then, Kong Yong
AU - Bastion, Mae Lynn Catherine
AU - Alzahrani, Badr
AU - Farhana, Aisha
AU - Muthuvenkatachalam, Bala Sundaram
AU - Samrot, Antony V.
AU - Swamy, K. B.
AU - Marraiki, Najat
AU - Elgorban, Abdallah M.
AU - Subbiah, Suresh Kumar
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/1
Y1 - 2020/1
N2 - Blindness and vision impairment are caused by irremediable retinal degeneration in affected individuals worldwide. Cell therapy for a retinal replacement can potentially rescue their vision, specifically for those who lost the light sensing photoreceptors in the eye. As such, well-characterized retinal cells are required for the replacement purposes. Stem cell-based therapy in photoreceptor and retinal pigment epithelium transplantation is well received, however, the drawbacks of retinal transplantation is the limited clinical protocols development, insufficient number of transplanted cells for recovery, the selection of potential stem cell sources that can be differentiated into the target cells, and the ability of cells to migrate to the host tissue. Dental pulp stem cells (DPSC) belong to a subset of mesenchymal stem cells, and are recently being studied due to its high capability of differentiating into cells of the neuronal lineage. In this review, we look into the potential uses of DPSC in treating retinal degeneration, and also the current data supporting its application.
AB - Blindness and vision impairment are caused by irremediable retinal degeneration in affected individuals worldwide. Cell therapy for a retinal replacement can potentially rescue their vision, specifically for those who lost the light sensing photoreceptors in the eye. As such, well-characterized retinal cells are required for the replacement purposes. Stem cell-based therapy in photoreceptor and retinal pigment epithelium transplantation is well received, however, the drawbacks of retinal transplantation is the limited clinical protocols development, insufficient number of transplanted cells for recovery, the selection of potential stem cell sources that can be differentiated into the target cells, and the ability of cells to migrate to the host tissue. Dental pulp stem cells (DPSC) belong to a subset of mesenchymal stem cells, and are recently being studied due to its high capability of differentiating into cells of the neuronal lineage. In this review, we look into the potential uses of DPSC in treating retinal degeneration, and also the current data supporting its application.
KW - Dental pulp stem cell
KW - Photoreceptor
KW - Retina
KW - Retinal degeneration
KW - Stem cell therapy
UR - http://www.scopus.com/inward/record.url?scp=85076497190&partnerID=8YFLogxK
U2 - 10.1016/j.jphotobiol.2019.111727
DO - 10.1016/j.jphotobiol.2019.111727
M3 - 短篇回顧評介論文
C2 - 31862637
AN - SCOPUS:85076497190
SN - 1011-1344
VL - 203
JO - Journal of Photochemistry and Photobiology B: Biology
JF - Journal of Photochemistry and Photobiology B: Biology
M1 - 111727
ER -