@inproceedings{acdb7711e0d544008705d269270347f7,
title = "Least invasive in vivo imaging using harmonic generation microscopy",
abstract = "In this manuscript, we review the physics and recent developments of the least invasive optical higher harmonic generation microscopy, with an emphasis on the in vivo molecular imaging applications. Optical higher harmonicgenerations, including second harmonic generation (SHG) and third harmonic generation (THG), leave no energy deposition to the interacted matters due to their energy-conservation characteristic, providing the {"}noninvasiveness{"} nature desirable for clinical studies. Combined with their nonlinearity, harmonic generation microscopy provides threedimensional sectioning capability, offering new insights into live samples. By choosing the lasers working in the high penetration window, we have recently developed a least-invasive in vivo light microscopy with submicron 3D resolution and high penetration, utilizing endogenous and resonantly-enhanced multi-harmonic- generation signals in live specimens, with focused applications on the developmental biology study and clinical virtual biopsy.",
keywords = "Harmonic generation microscopy, Higher harmonic generation, Molecular imaging, Noninvasive microscopy, Resonance enhancement, Second harmonic generation, Third harmonic generation, Virtual biopsy",
author = "Chen, {Szu Yu} and Tai, {Shih Peng} and Hsieh, {Cho Shuen} and Chen, {Chao Yu} and Yu, {Che Hang} and Lee, {Yen Wei} and Lee, {Wen Jeng} and Chen, {Shee Uan} and Chang, {Fu Hsiung} and Sun, {Chi Kuang}",
year = "2008",
doi = "10.1117/12.760560",
language = "???core.languages.en_GB???",
isbn = "9780819470355",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Multiphoton Microscopy in the Biomedical Sciences VIII",
note = "Multiphoton Microscopy in the Biomedical Sciences VIII ; Conference date: 20-01-2008 Through 22-01-2008",
}