@inproceedings{c3786bdbbb774b83abc20be62704b39c,
title = "Interfacing multiplexed microfluidics to MALDI-MS by high-throughput robotic spotting",
abstract = "Direct and automated spotting of analyte from multichannel microfluidic chips is demonstrated as a simple, robust, and high-throughput method for interfacing arrays of parallel microchannels with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Using cyclic olefin copolymer (COC) chips containing 8 parallel 100 µm x 46 µm channels connected to a single input port, excellent spotting volume repeatability and MALDI-MS signal uniformity are achieved for a panel of sample peptides. Using the robotic spotting approach, chip-based reversed-phase liquid chromatography (RPLC) separations are interfaced with nanofilament silicon LDI-MS, demonstrating the potential for this approach towards high-throughput on-chip bioanalysis coupled seamlessly with back-end mass spectrometry.",
author = "Tsao, {C. W.} and T. Song and Chen, {C. F.} and J. Liu and Chang, {C. C.} and Devoe, {D. L.}",
note = "Publisher Copyright: {\textcopyright} 2008 TRF.; 2008 Solid-State Sensors, Actuators, and Microsystems Workshop ; Conference date: 01-06-2008 Through 05-06-2008",
year = "2008",
doi = "10.31438/trf.hh2008.31",
language = "???core.languages.en_GB???",
series = "Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop",
publisher = "Transducer Research Foundation",
pages = "110--113",
editor = "Turner, {Kimberly L.} and Leland Spangler",
booktitle = "2008 Solid-State Sensors, Actuators, and Microsystems Workshop",
}