Integrating adaptive mutations and family competition with differential evolution for flexible ligand docking

J. M. Yang; J. T. Horng; C. Y. Kao

Integrating adaptive mutations and family competition with differential evolution for flexible ligand docking

J. M. Yang, J. T. Horng, C. Y. Kao

資訊工程學系

研究成果: 會議貢獻類型 › 會議論文 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

A flexible ligand docking protocol based on evolutionary algorithms is investigated. The proposed approach integrates decreasing-based mutations and self-adaptive mutations with differential evolution. This approach possesses global and local search strategies to balances the trade-off between exploitation and exploration of the search. The proposed approach is applied to a dihydrofolate reductase enzyme with the anti-cancer drug methotrexate and two analogues of antibacterial drug trimethoprim. Numerical results indicate that the new approach is very robust.

原文	???core.languages.en_GB???
頁面	473-480
頁數	8
出版狀態	已出版 - 2001
事件	Congress on Evolutionary Computation 2001 - Soul, Korea, Republic of 持續時間: 27 5月 2001 → 30 5月 2001

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???event.eventtypes.event.conference???	Congress on Evolutionary Computation 2001
國家/地區	Korea, Republic of
城市	Soul
期間	27/05/01 → 30/05/01

UN SDG

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abstract = "A flexible ligand docking protocol based on evolutionary algorithms is investigated. The proposed approach integrates decreasing-based mutations and self-adaptive mutations with differential evolution. This approach possesses global and local search strategies to balances the trade-off between exploitation and exploration of the search. The proposed approach is applied to a dihydrofolate reductase enzyme with the anti-cancer drug methotrexate and two analogues of antibacterial drug trimethoprim. Numerical results indicate that the new approach is very robust.",

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AU - Yang, J. M.

AU - Horng, J. T.

AU - Kao, C. Y.

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Y1 - 2001

N2 - A flexible ligand docking protocol based on evolutionary algorithms is investigated. The proposed approach integrates decreasing-based mutations and self-adaptive mutations with differential evolution. This approach possesses global and local search strategies to balances the trade-off between exploitation and exploration of the search. The proposed approach is applied to a dihydrofolate reductase enzyme with the anti-cancer drug methotrexate and two analogues of antibacterial drug trimethoprim. Numerical results indicate that the new approach is very robust.

AB - A flexible ligand docking protocol based on evolutionary algorithms is investigated. The proposed approach integrates decreasing-based mutations and self-adaptive mutations with differential evolution. This approach possesses global and local search strategies to balances the trade-off between exploitation and exploration of the search. The proposed approach is applied to a dihydrofolate reductase enzyme with the anti-cancer drug methotrexate and two analogues of antibacterial drug trimethoprim. Numerical results indicate that the new approach is very robust.

UR - http://www.scopus.com/inward/record.url?scp=0034871142&partnerID=8YFLogxK

M3 - 會議論文

AN - SCOPUS:0034871142

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T2 - Congress on Evolutionary Computation 2001

Y2 - 27 May 2001 through 30 May 2001

ER -

Integrating adaptive mutations and family competition with differential evolution for flexible ligand docking

摘要

???event.eventtypes.event.conference???

UN SDG

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