Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

Children's Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium

研究成果: 雜誌貢獻期刊論文同行評審

160 引文 斯高帕斯(Scopus)

摘要

We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblastoma (22), ganglioglioma (18), craniopharyngioma (16), and atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span histological boundaries, suggesting that treatments used for one histological type may be applied effectively to other tumors sharing similar proteomics features. Immune landscape characterization reveals diverse tumor microenvironments across and within diagnoses. Proteomics data further reveal functional effects of somatic mutations and copy number variations (CNVs) not evident in transcriptomics data. Kinase-substrate association and co-expression network analysis identify important biological mechanisms of tumorigenesis. This is the first large-scale proteogenomics analysis across traditional histological boundaries to uncover foundational pediatric brain tumor biology and inform rational treatment selection.

原文???core.languages.en_GB???
頁(從 - 到)1962-1985.e31
期刊Cell
183
發行號7
DOIs
出版狀態已出版 - 23 12月 2020

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