With the penetration of renewable energy, the power quality (PQ) becomes the important issue for operation stability of power system. The efficient monitoring mechanism for different multiple PQ disturbances is the fundamental infrastructure for modernization of power system. However, the diverse PQ signals result in numerous analysis techniques and make the integration of PQ monitoring difficult. To resolve the above-mentioned problem, the Prony-based PQ analysis mechanism is proposed in this paper. The commonly seen PQ disturbances, such as the fundamental frequency deviation, harmonics, interharmonics, voltage fluctuations (flickers), and PQ events, can be easily analyzed and detected with Prony-based technique and integrated for the design of monitoring system. The performance of proposed analysis mechanism can be verified by the implementation in the Pingtung ac microgrid of Taiwan.