Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone Part 1 of 2

Tu Lee; Yan Chan Su; Hung Ju Hou; Hsiang Yu Hsieh

Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone Part 1 of 2

Tu Lee, Yan Chan Su, Hung Ju Hou, Hsiang Yu Hsieh

化學工程與材料工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, and crystal habits of crystals of active pharmaceutical ingredients. The literature, however, provides little advice for identifying the best solvent combinations. The authors describe the importance of a rapid and an abbreviated screening strategy by initial solvent screening in 20-mL scintillation vials.

原文	???core.languages.en_GB???
頁（從 - 到）	62-72
頁數	11
期刊	Pharmaceutical Technology
卷	33
發行號	5
出版狀態	已出版 - 5月 2009

引用此

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AB - Many processes such as spherical crystallization, microemulsions, and organic nanocrystal fabrication require combinations of several solvents. A solution's composition ratio at the time of nucleation greatly influences the solubility, polymorphism, and crystal habits of crystals of active pharmaceutical ingredients. The literature, however, provides little advice for identifying the best solvent combinations. The authors describe the importance of a rapid and an abbreviated screening strategy by initial solvent screening in 20-mL scintillation vials.

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Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone Part 1 of 2

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