TY - JOUR
T1 - Inhibitory control and the frontal eye fields
AU - Muggleton, Neil G.
AU - Chen, Chiao Yun
AU - Tzeng, Ovid J.L.
AU - Hung, Lan
AU - Juan, Chi Hung
N1 - Funding Information:
The authors are grateful to the reviewersʼ constructive comments and suggestions. This work was sponsored by the National Science Council, Taiwan (96-2413-H-008-001-MY3, 97-2511-S- 008-005-MY3, 98-2410-H-008-010-MY3, 98-2517-S-004-001-MY3, 97-2511-S-008-008-MY5). N. G. M. was supported by the UK Medical Research Council. C. H. J. was supported by the National Science Council, Taiwan (98-2918-I-008-011), and the Fulbright scholarship, USA.
PY - 2010/12
Y1 - 2010/12
N2 - Inhibitory control mechanisms are important in a range of behaviors to prevent execution of motor acts which, having been planned, are no longer necessary. Ready examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution or inhibition of a bat swing must be made in a brief time interval. The role of the FEFs, an area typically described in relation to eye movement functions but also involved in visual processes, was investigated in an inhibitory control task using transcranial magnetic stimulation (TMS). A stop signal task with manual responses was used, providing measures of impulsivity and inhibitory control. TMS over FEF had no effect on response generation (impulsivity, indexed by go signal RT) but disrupted inhibitory control (indexed by stop signal RT). This is the first demonstration of a role for FEF in this type of task in normal subjects in a task which did not require eye movements and complements previous TMS findings of roles for pre-SMA and inferior frontal gyrus (IFG) in inhibitory control.
AB - Inhibitory control mechanisms are important in a range of behaviors to prevent execution of motor acts which, having been planned, are no longer necessary. Ready examples of this can be seen in a range of sports, such as cricket and baseball, where the choice between execution or inhibition of a bat swing must be made in a brief time interval. The role of the FEFs, an area typically described in relation to eye movement functions but also involved in visual processes, was investigated in an inhibitory control task using transcranial magnetic stimulation (TMS). A stop signal task with manual responses was used, providing measures of impulsivity and inhibitory control. TMS over FEF had no effect on response generation (impulsivity, indexed by go signal RT) but disrupted inhibitory control (indexed by stop signal RT). This is the first demonstration of a role for FEF in this type of task in normal subjects in a task which did not require eye movements and complements previous TMS findings of roles for pre-SMA and inferior frontal gyrus (IFG) in inhibitory control.
UR - http://www.scopus.com/inward/record.url?scp=78649485811&partnerID=8YFLogxK
U2 - 10.1162/jocn.2010.21416
DO - 10.1162/jocn.2010.21416
M3 - 期刊論文
C2 - 20044887
AN - SCOPUS:78649485811
SN - 0898-929X
VL - 22
SP - 2804
EP - 2812
JO - Journal of Cognitive Neuroscience
JF - Journal of Cognitive Neuroscience
IS - 12
ER -