In vivo harmonic generation biopsy of human skin

Szu Yu Chen, Hai Yin Wu, Chi Kuang Sun

研究成果: 雜誌貢獻期刊論文同行評審

83 引文 斯高帕斯(Scopus)


The ability to in vivo image deep tissues noninvasively with a high resolution is strongly required for optical virtual biopsy. Higher harmonic generation microscopy, combined with second- and third-harmonic generation microscopies, is applied to 17 Asian volunteers' forearm skin. After continuous observation for 30 min, no visible damage was found. Our study proves that harmonic generation biopsy (HGB) is able to satisfy the safety requirement and to provide high penetrability (∼300 μm) and submicron resolution all at the same time and is a promising tool for future virtual biopsy of skin diseases. In contrast to a previous study on fixed human skin specimens, a much improved penetrability and much reduced resolution-degradation versus depth are found in this in vivo examination.

期刊Journal of Biomedical Optics
出版狀態已出版 - 2009


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