摘要
We develop a new concept to impart new functions to biocatalysts by combining enzymes and metal-organic frameworks (MOFs). The proof-of-concept design is demonstrated by embedding catalase molecules into uniformly sized ZIF-90 crystals via a de novo approach. We have carried out electron microscopy, X-ray diffraction, nitrogen sorption, electrophoresis, thermogravimetric analysis, and confocal microscopy to confirm that the ∼10 nm catalase molecules are embedded in 2 μm single-crystalline ZIF-90 crystals with ∼5 wt % loading. Because catalase is immobilized and sheltered by the ZIF-90 crystals, the composites show activity in hydrogen peroxide degradation even in the presence of protease proteinase K.
原文 | ???core.languages.en_GB??? |
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頁(從 - 到) | 4276-4279 |
頁數 | 4 |
期刊 | Journal of the American Chemical Society |
卷 | 137 |
發行號 | 13 |
DOIs | |
出版狀態 | 已出版 - 8 4月 2015 |