How physics can help in understanding cardiac rhythms? Predicting & control of complex oscillatory behavior

Shiuan Ni Liang, Duy Manh Le, Wei Yin Chiang, Pik Yin Lai, C. K. Chan

研究成果: 書貢獻/報告類型會議論文篇章同行評審

摘要

We discuss our recent theoretical and experimental work in cardiac systems. The first is about the rhythmic variation as the cardiac myocyte cell culture synchronized, and how it can be explained in terms of the frequency enhancement phenomenon in coupled excitable systems. Another work concerns the prediction of self-terminating ventricular fibrillations (VF) based on the analysis of time-series signals from ventricles and near the sinus atrial node by the cross-wavelet power spectrum and cross-Fourier power spectrum methods. The success rate of our prediction criteria is about 80-90%. Our findings suggest that a heart under VF can recover its sinus rhythm only when the sino-atrial node of the heart is not under strong influence of the VF from its ventricle. Finally the dramatic reduction of cardiac alternans by small perturbations in pacing scheme. Alternans are alternating long and short action potential durations in heart beats, which is a precursor of the fatal. Predictions and validity of this control method have been verified by both experiments performed with isolated heart preparations and numerical simulations. A nonlinear return map for this novel pacing scheme based on action potential duration restitution response is proposed to explain the working mechanism of the control. Extending this novel control method to general complex dynamics can be achieved.

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主出版物標題2014 International Conference on Physics, ICP 2014
發行者Atlantis Press
頁面1-7
頁數7
ISBN(電子)9789462520387
出版狀態已出版 - 2014
事件2014 International Conference on Physics, ICP 2014 - Yogyakarta, Indonesia
持續時間: 25 8月 201426 8月 2014

出版系列

名字2014 International Conference on Physics, ICP 2014

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???event.eventtypes.event.conference???2014 International Conference on Physics, ICP 2014
國家/地區Indonesia
城市Yogyakarta
期間25/08/1426/08/14

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