High Precision DNA Modification Analysis of HCG9 in Major Psychosis

Mrinal Pal, Sasha Ebrahimi, Gabriel Oh, Tarang Khare, Aiping Zhang, Zachary A. Kaminsky, Sun Chong Wang, Arturas Petronis

研究成果: 雜誌貢獻期刊論文同行評審

15 引文 斯高帕斯(Scopus)

摘要

New epigenetic technologies may uncover etiopathogenic mechanisms of major psychosis. In this study, we applied padlock probe-based ultra-deep bisulfite sequencing for fine mapping of modified cytosines of the HLA complex group 9 (nonprotein coding) gene in the postmortem brains of individuals affected with schizophrenia or bipolar disorder and unaffected controls. Significant differences between patients and controls were detected in both CpG and CpH modifications. In addition, we identified epigenetic age effects, DNA modification differences between sense and anti-sense strands, and demonstrated how DNA modification data can be used in clustering of patient populations. Our findings revealed new epigenetic complexities but also highlighted the potential of DNA modification approaches in the search of heterogeneous causes of major psychiatric disease.

原文???core.languages.en_GB???
頁(從 - 到)170-177
頁數8
期刊Schizophrenia Bulletin
42
發行號1
DOIs
出版狀態已出版 - 1 1月 2016

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