Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation

Mei Chan Sin, Wen Lin Lin, Jeff Chang Hung Chen, Akon Higuchi, Jie Zheng, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Yung Chang

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)

摘要

A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.

原文???core.languages.en_GB???
頁(從 - 到)409-420
頁數12
期刊International Journal of Polymeric Materials and Polymeric Biomaterials
65
發行號8
DOIs
出版狀態已出版 - 23 5月 2016

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