TY - JOUR
T1 - Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation
AU - Sin, Mei Chan
AU - Lin, Wen Lin
AU - Chen, Jeff Chang Hung
AU - Higuchi, Akon
AU - Zheng, Jie
AU - Chinnathambi, Arunachalam
AU - Alharbi, Sulaiman Ali
AU - Chang, Yung
N1 - Publisher Copyright:
Copyright © 2016 Taylor & Francis Group, LLC.
PY - 2016/5/23
Y1 - 2016/5/23
N2 - A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.
AB - A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.
KW - Bio-inspired coating
KW - PEGylatedpoly (ethyleneimine)
KW - hemocompatibility
KW - material versatility
KW - thermal-activated self-copolymerization
UR - http://www.scopus.com/inward/record.url?scp=84958260576&partnerID=8YFLogxK
U2 - 10.1080/00914037.2015.1129953
DO - 10.1080/00914037.2015.1129953
M3 - 期刊論文
AN - SCOPUS:84958260576
SN - 0091-4037
VL - 65
SP - 409
EP - 420
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 8
ER -