This special issue focus on underlying research with the use of human-centered AI (Artificial Intelligence), where the new design methods and tools can be leveraged and evaluated, hopes to advance AI research, education, policy, and practice to improve the human condition in education. This special issue intends to advocate an in-depth dialogue between researchers with diverse thoughts, genders, ethnicity, and cultures, as well as across disciplines, leading to a better understanding of human-centered AI. Beneficial interactions between researchers could enhance the adoption of human-centered AI in education. This special issue includes ten papers demonstrating how to augment human intelligence with machine intelligence. The ten papers feature human-centered AI in education, AI in language education, AI in learning analytics, ethical reasoning, AI in the clinical workplace, intelligent education robots, AI risk framework, intelligent course recommendation, education chatbots, and intelligent assessment.