GPS radio occultation (RO) signals are highly coherent and precise, and thus sufficient for holographic investigation of the atmosphere, ionosphere, and the Earth's surface from space. In principle, three-dimensional radio-holographic remote sensing is possible by using new radio holographic equations to retrieve the radio field within the atmosphere from a radio field known at some interface outside the atmosphere. A simplified two-dimensional form of the radio-holographic equations which are developed under an assumption of local spherical symmetry can be used to obtain two-dimensional radio images of the atmosphere and terrestrial surface. To achieve this, radio holograms recorded by a GPS receiver onboard a low earth orbit (LEO) satellite at two GPS frequencies can be used and focused synthetic aperture principle applied. Analysis of GPS/MET RO data is presented to show the effectiveness of a radio-holographic approach. It is shown that the amplitude of GPS radio signals (in addition to phase data) can be used to obtain detailed altitude profiles of the vertical gradient of refractivity in the atmosphere and electron density in the mesosphere. The results demonstrate the applicability of GPS radio holography for a detailed global study of the natural processes in the atmosphere and mesosphere.