Facile Synthesis of TiO2-SiO2-P2O5/CaO/ZnO with a Core-Shell Structure for Bone Implantation

Ekaterina S. Lyutova, Valeriya A. Tkachuk, Liliya A. Selyunina, Lyudmila P. Borilo, Dmitriy A. Fedorishin, Yu Wen Chen

研究成果: 雜誌貢獻期刊論文同行評審


A facile synthesis method was developed to synthesize TiO2-SiO2-P2O5/CaO or TiO2-SiO2-P2O5/ZnO with a core-shell structure. The carboxylic cation exchanger Tokem-250 has a high selectivity for Ca2+/Zn2+ ions and was used in this study. The framework of the material in the shell was TiO2-SiO2-P2O5, and the inner part was filled with CaO (sample TiO2-SiO2/CaO) or ZnO (sample TiO2-SiO2-P2O5/ZnO). A stepwise heat treatment (drying in a drying oven at 60 °C for 30 min, then annealing in a muffle furnace for 30 min at 150, 250, and 350 °C, at 600 °C for 6 h, and at 800 °C for 1 h) was needed to obtain a homogeneous material. The poly(vinyl alcohol) was used as a binding additive. The obtained composites were characterized by a regular structure and highly developed surface. The samples exhibit bioactive properties in the simulated body fluid (SBF) solution, since the surface contains active centers (Si4+, Ti4+) which contribute to mineralization and precipitation of the calcium-phosphate compounds on the surface from biological media. The TiO2-SiO2-P2O5/CaO-PVA samples did not exceed acceptable hemolysis levels for medical materials.

頁(從 - 到)46564-46572
期刊ACS Omega
出版狀態已出版 - 20 12月 2022


深入研究「Facile Synthesis of TiO2-SiO2-P2O5/CaO/ZnO with a Core-Shell Structure for Bone Implantation」主題。共同形成了獨特的指紋。