@article{a31666a6c78346e09b993518b9a59e76,
title = "External stimulus-responsive biomaterials designed for the culture and differentiation of ES, IPS, and adult stem cells",
abstract = "The physical and chemical characteristics of biomaterial surface and hydrogels can be altered by external stimuli, such as light irradiation, temperature changes, pH shifts, shear stress forces, electrical forces, and the addition of small chemical molecules. Such external stimulus-responsive biomaterials represent promising candidates that have been developed for the culture and differentiation of embryonic stem (ES) cells, induced pluripotent stem (iPS) cells, and adult stem cells. Biomaterials that are designed to respond in a reversible manner to specific external signals can be formed on micropatterned or non-micropatterned surface, in hydrogels, or on microcarriers. Stem cells and the cells differentiated from them into specific tissue lineages can be cultured and/or differentiated on dishes with immobilized external stimulus-responsive polymers. Cells can be detached from these dishes without using an enzymatic digestion method or a mechanical method when the appropriate external stimulus is generated on the surface. This review discusses the polymers and polymeric designs employed to produce surface and hydrogels for stem cell culture, differentiation, and/or cell detachment using various external stimuli.",
keywords = "Biomaterial, Microcarrier, Photoresponsive, Stem cell, Thermoresponsive, Thixotropic",
author = "Akon Higuchi and Ling, {Qing Dong} and Kumar, {S. Suresh} and Yung Chang and Kao, {Ta Chun} and Munusamy, {Murugan A.} and Alarfaj, {Abdullah A.} and Hsu, {Shih Tien} and Akihiro Umezawa",
note = "Funding Information: This research was partially supported by the National Science Council of Taiwan under Grant numbers 101-2120-M-008-003, 102-2120-M-008-002, and 102-2221-E-008-112-MY2 . This work was also supported by the LandSeed Hospital project ( NCU-LSH-101-A-001 and NCU-LSH-102-A-003 ), the National Defense Medical Center Project ( 102NCU-NDMC-01 ), and the Cathay General Hospital Project ( 101CGH-NCU-A2, 102NCU-CGH-02, CGH-MR-10025, CGH-MR-10103, CGH-MR-10115, and CGH-MR-A10204 ). A Grant-in-Aid for Scientific Research (number 24560968 ) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan is also acknowledged. We acknowledge the International High Cited Research Group (IHCRG # 14-104), Deanship of Scientific Research, King Saud University, Riyadh, Kingdom of Saudi Arabia. Akon Higuchi thanks King Saud University, Riyadh, Kingdom of Saudi Arabia, for the Visiting Professorship.",
year = "2014",
month = sep,
doi = "10.1016/j.progpolymsci.2014.05.001",
language = "???core.languages.en_GB???",
volume = "39",
pages = "1585--1613",
journal = "Progress in Polymer Science",
issn = "0079-6700",
number = "9",
}