Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

Chiang Wen Lee, Lee Fen Hsu, I. Lin Wu, Yung Li Wang, Wei Chen Chen, Yan Jun Liu, Lu Tang Yang, Chong Lun Tan, Yueh Hsia Luo, Chia Ching Wang, Hui Wen Chiu, Thomas Chung Kuang Yang, Yen Yue Lin, Hsin An Chang, Yao Chang Chiang, Ching Hsiang Chen, Ming Hsueh Lee, Kuo Ti Peng, Cathy Chia Yu Huang

研究成果: 雜誌貢獻期刊論文同行評審

59 引文 斯高帕斯(Scopus)


Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially in the hippocampus of these mice. Concurrently, the hippocampus had decreased levels of immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, and elevated neuroinflammation, all of which are critical for synaptic plasticity and memory. Interestingly, ablation of the vagus nerve, a modulator of the gut-brain axis, improved the memory function of PS-MPs mice. These results indicate that exposure to PS-MPs in mice alters the expression of neuronal activity-dependent genes and synaptic proteins, and increases neuroinflammation in the hippocampus, subsequently causing behavioral changes through the vagus nerve-dependent pathway. Our findings shed light on the adverse impacts of PS-MPs on the brain and hippocampal learning and memory.

期刊Journal of Hazardous Materials
出版狀態已出版 - 15 5月 2022


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