Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation

Hsiang Ying Chen, Yi Teng Hsiao, Shu Chen Liu, Tien Hsu, Wei Yen Woon, I. Lin

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)

摘要

We report the experimental observation of speeded-up collective motion of the monolayer endothelia-cancer mixture on a collagen-coated substrate, after the invasion of a small fraction of motile cancer cells into the confluent endothelial monolayer, through disrupting cell-cell junctions. It is found that, with an increasing waiting time, the cancer-free confluent endothelial monolayer exhibits a dynamical slowing-down of liquidlike micromotion with a gradually decreasing degree of superdiffusion. After invasion, cancer cells aggregate and exhibit turbulentlike cooperative motion, which is enhanced with the increasing size of gradually aggregated cancer clusters, confined by the fluctuating boundaries of surrounding endothelial cells. It, in turn, enhances the surrounding endothelial cell motion and speeds up the originally slowed-down motion.

原文???core.languages.en_GB???
文章編號018101
期刊Physical Review Letters
121
發行號1
DOIs
出版狀態已出版 - 3 7月 2018

指紋

深入研究「Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation」主題。共同形成了獨特的指紋。

引用此