@inproceedings{646341e3e371483fa1584b4144da3214,
title = "Enhancement of DNA hybridization efficiency using photovoltaic effect",
abstract = "We present a novel method to enhance the DNA hybridization efficiency by photovoltaic effect. The arrayed microchip is fabricated in a semiconductor wafer coated with metal thin films for immobilizing the probe DNA. Hybridization in between immobilized probe DNAs and fluorescent-labeled target DNA are carried out through the illumination of a laser. Photovoltaic effect induces positive charges on the surface of microchip to attract negatively charged target DNAs down to the hybridization site, results in efficiently enhancing the hybridization rate up to two-order magnitude. Our observation provided cutting-edge solution away from bottleneck of microchip process in heat and time-consuming.",
author = "Chen, {Chii Chang} and Ku, {Wei Chu} and Chiu, {Sung Kay} and Tzeng, {Chi Meng}",
note = "Publisher Copyright: {\textcopyright} 2003 IEEE.; 5th Pacific Rim Conference on Lasers and Electro-Optics, CLEO/Pacific Rim 2003 ; Conference date: 15-12-2003 Through 19-12-2003",
year = "2003",
doi = "10.1109/CLEOPR.2003.1277271",
language = "???core.languages.en_GB???",
series = "Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "733",
booktitle = "CLEO/Pacific Rim 2003 - 5th Pacific Rim Conference on Lasers and Electro-Optics",
}
