Enantioselective additions of aryltitanium tris(isopropoxide) to ketones: Structure of [(i-PrO)2Ti{μ-(S)-BINOLate}(μ-O-i-Pr)TiPh(O-i-Pr) 2], study of mechanistic and stereochemical insights

Kuo Hui Wu, Yi Yin Kuo, Chien An Chen, Yi Ling Huang, Han Mou Gau

研究成果: 雜誌貢獻期刊論文同行評審

26 引文 斯高帕斯(Scopus)

摘要

Aryl addition reactions of ArTi(O-i-Pr)3 to aromatic, heteroaromatic, or α,β-unsaturated ketones are described, producing tertiary alcohols in good to excellent enantioselectivities of up to 97% ee. The structure of the dititanium complex [(i-PrO)2Ti{μ-(S)-BINOLate} (μ-O-i-Pr)TiPh(O-i-Pr)2] [(S)-4] that simultaneously bears a chiral directing ligand and a nucleophile is reported. Complex (S)-4 possesses a pocket structure and has been illustrated as the key active species for addition reactions of both aldehydes and ketones. Mechanistic and stereochemical insights concerning addition reactions of organometallic reagents to organic carbonyls are rationalized based on the pocket structure and pocket size of (S)-4.

原文???core.languages.en_GB???
頁(從 - 到)1001-1008
頁數8
期刊Advanced Synthesis and Catalysis
355
發行號5
DOIs
出版狀態已出版 - 25 3月 2013

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