Effects of Scale-Up and Impeller Types on Spherical Agglomeration of Dimethyl Fumarate

Chih Wei Chen, Hung Lin Lee, Kuan Lin Yeh, Tu Lee

研究成果: 雜誌貢獻期刊論文同行評審

6 引文 斯高帕斯(Scopus)

摘要

Spherical agglomeration (SA) allows for intensifying a crystallization process through simultaneous particle size enlargement and process efficiency enhancement, without a compromise between bioavailability and processability of active pharmaceutical ingredients (APIs). Inefficient collision intensity may encounter during scale-up of an SA process, while mixing intensity and flow patterns do play critical roles especially in a batchwise stirred tank. In the present study, the scalability of an SA process by operating at all the same configurations of different scales, 0.5, 2, and 10 L, using a common one-layered impeller with four pitched blades was examined through the use of dimethyl fumarate as a model API. Insights into the guidelines for scaling up of the SA process are also given. Furthermore, the effects of impeller types, including the one-layered impeller, the two-layered impeller with four pitched blades, and the maxblend impeller, on the size, size distribution, and roundness of dimethyl fumarate agglomerates were investigated carefully.

原文???core.languages.en_GB???
頁(從 - 到)11555-11567
頁數13
期刊Industrial and Engineering Chemistry Research
60
發行號30
DOIs
出版狀態已出版 - 4 8月 2021

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