Effects of particulate matter on inflammatory markers in the general adult population

Dai Hua Tsai, Nadia Amyai, Pedro Marques-Vidal, Jia Lin Wang, Michael Riediker, Vincent Mooser, Fred Paccaud, Gerard Waeber, Peter Vollenweider, Murielle Bochud

研究成果: 雜誌貢獻期刊論文同行評審

85 引文 斯高帕斯(Scopus)

摘要

Background: Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway.Methods: We used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM10 (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) by robust linear regressions, controlling for potential confounding factors and assessing effect modification.Results: In adjusted analyses, for every 10 μg/m3 elevation in PM10, IL-1ß increased by 0.034 (95 % confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-α by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels.Conclusions: Short-term exposure to PM10 was positively associated with higher levels of circulating IL-1ß, IL-6 and TNF-α in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM10 to cardiovascular risk.

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文章編號24
期刊Particle and Fibre Toxicology
9
DOIs
出版狀態已出版 - 6 7月 2012

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