Effects of morphology and oxygen supply on schizophyllan formation by Schizophyllum commune using a pellet size controlling bioreactor

Chin Hang Shu, Pou Fu Chou, I. Ching Hsu

研究成果: 雜誌貢獻期刊論文同行評審

10 引文 斯高帕斯(Scopus)

摘要

The effects of mycelial morphology and oxygen supply on the production of the anti-tumor polysaccharide from Schizophyllum commune were evaluated in this study. A pellet size controlling bioreactor has been used successfully for the production of the anti-tumor polysaccharide of S commune. The average pellet size of mycelia in a bubble column bioreactor was around 20.5 mm in a typical run without using pellet size control. By forcing the fermentation broth through a pellet size control device with a stainless screen at five different fermentation times ranging from 1.0 to 4.5 days in each batch, different fungal pellet sizes ranging from 12.3 to 3.0 mm were achieved. The formation of anti-tumor polysaccharide, schizophyllan (SPG), was significantly associated with the pellet morphology and oxygen supply rate. An optimal product yield of 0.29 g g-1 glucose was obtained when the pellet size was controlled at 12.3 mm. Oxygen transfer limitation inside the pellets was responsible for the formation of entrapped polysaccharide. Maximum entrapped SPG yield (Yp/s entrapped) of 0.88 g g-1 glucose occurred at the optimal pellet size of 12.3 mm.

原文???core.languages.en_GB???
頁(從 - 到)1383-1388
頁數6
期刊Journal of Chemical Technology and Biotechnology
80
發行號12
DOIs
出版狀態已出版 - 12月 2005

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