摘要
The effects of culture pH on the production, molecular weight distribution and the bioactivity of polysaccharides produced by Agaricus blazei were evaluated by four pH-controlled batch cultures. As the culture pH of each batch was controlled from 4.0 to 7.0, the maximum polysaccharide concentration increased from 561 to 1252 mg dm-3, but the average molecular weight of the polysaccharides decreased monotonically from 1080 kDa to 600 kDa, the relative amount of β-glucan from 56% to 33%, and the TNF-α release by macrophage cells from 1440 to 760 pg per 5 × 104 cells. Polysaccharides with higher molecular weights, β-glucan contents and bioactivities were obtained in the submerged cultures of Agaricus blazei at lower culture pH but with lower yields.
原文 | ???core.languages.en_GB??? |
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頁(從 - 到) | 998-1002 |
頁數 | 5 |
期刊 | Journal of Chemical Technology and Biotechnology |
卷 | 79 |
發行號 | 9 |
DOIs | |
出版狀態 | 已出版 - 9月 2004 |