Effects of culture pH on the production of bioactive polysaccharides by Agaricus blazei in batch cultures

Chin Hang Shu, Ko Jung Lin, Bor Jiun Wen

研究成果: 雜誌貢獻期刊論文同行評審

20 引文 斯高帕斯(Scopus)

摘要

The effects of culture pH on the production, molecular weight distribution and the bioactivity of polysaccharides produced by Agaricus blazei were evaluated by four pH-controlled batch cultures. As the culture pH of each batch was controlled from 4.0 to 7.0, the maximum polysaccharide concentration increased from 561 to 1252 mg dm-3, but the average molecular weight of the polysaccharides decreased monotonically from 1080 kDa to 600 kDa, the relative amount of β-glucan from 56% to 33%, and the TNF-α release by macrophage cells from 1440 to 760 pg per 5 × 104 cells. Polysaccharides with higher molecular weights, β-glucan contents and bioactivities were obtained in the submerged cultures of Agaricus blazei at lower culture pH but with lower yields.

原文???core.languages.en_GB???
頁(從 - 到)998-1002
頁數5
期刊Journal of Chemical Technology and Biotechnology
79
發行號9
DOIs
出版狀態已出版 - 9月 2004

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