Dual-functional gold-iron oxide core-satellite hybrid nanoparticles for sensitivity enhancement in biosensors: Via nanoplasmonic and preconcentration effects

Yi Chen Chen, Yu Chen Chou, Jui Han Chang, Li Ting Chen, Chun Jen Huang, Lai Kwan Chau, Yen Ling Chen

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

A common strategy to improve the sensitivity of a biosensor for the detection of a low abundance analyte is to preconcentrate the analyte molecules before detection. A dual-functional gold-iron oxide core-satellite hybrid nanoparticle structure is proposed in this work to overcome the drawbacks of traditional sample pretreatment methods and the methods using non-magnetic nanomaterials for sample pretreatment. The new dual-functional hybrid nanoparticle structure can simultaneously serve as a signal reporter of a biorecognition event and a preconcentrator of a target at an extremely low concentration in a nanoplasmonic biosensor. By utilizing a fiber optic nanogold-linked sorbent assay in the fiber optic particle plasmon resonance (FOPPR) biosensor and an arbitrary DNA sequence as a target, we have demonstrated that the use of the new hybrid nanoparticle structure with magnetic preconcentration improves the limit of detection (LOD) for the DNA by 18 times as compared to the same method without magnetic preconcentration, so that the LOD for detecting the DNA can be as low as 2.6 fM. The new hybrid nanoparticle structure is easy to prepare and its use in the high-sensitivity and low-cost FOPPR biosensor provides vast opportunities in point-of-care applications. This journal is

原文???core.languages.en_GB???
頁(從 - 到)6935-6943
頁數9
期刊Analyst
146
發行號22
DOIs
出版狀態已出版 - 21 11月 2021

指紋

深入研究「Dual-functional gold-iron oxide core-satellite hybrid nanoparticles for sensitivity enhancement in biosensors: Via nanoplasmonic and preconcentration effects」主題。共同形成了獨特的指紋。

引用此