Development of lipid targeting Raman probes for in vivo imaging of Caenorhabditis elegans

Shobhit Charan, Fan Ching Chien, Narendra Singh, Chiung Wen Kuo, Peilin Chen

研究成果: 雜誌貢獻期刊論文同行評審

24 引文 斯高帕斯(Scopus)

摘要

A simple, sensitive, and highly specific lipid targeting Raman probe (Nile red coated silver nanoparticles) has been developed to image living nematode Caenorhabditis elegans (C. elegans). Our idea of imaging lipids in C. elegans is to combine the specificity of the fluorescent dye, Nile red, and the highly enhanced Raman scattering on the silver nanoparticles. Our strategy involves the fabrication of a lipid targeting probe, which is incorporated into the intracellular intestinal granules of C. elegans by incubating these worms in the solution containing Raman probes, resulting in an uptake and subsequent incorporation of these Raman probes into the intestinal granule, thus allowing fast visualization of lipid droplets through a conventional confocal imaging technique.

原文???core.languages.en_GB???
頁(從 - 到)5165-5170
頁數6
期刊Chemistry - A European Journal
17
發行號18
DOIs
出版狀態已出版 - 26 4月 2011

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