Development of capacitance measurement system for human serum albumin detection

J. Z. Tsai, C. J. Chen, J. T. Liu, Y. M. Hsin, W. Y. Chen, K. H. Hsueh

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)


The use of interdigitated electrodes and binding with Cibacron blue F3GA by self-assembly technology, which has high affinity for human serum albumin (HSA), and serves as a receptor for HSA detection, is reported. In preliminary tests, the interdigitated chip measured the impedance of HSA by electrochemical impedance spectroscopy and this result indicated the characteristic frequency of impedance change below 1.1kHz. However, a portable capacitance measurement system made using a standard operational amplifier circuit and AC excitation was applied at 1kHz. The detection result showed a significant linear correlation between HSA concentration (0.1 to 1mg/ml) and output voltage. The regression equation was Y=17.91+323.72X with R2=0.999. This reported study has successfully demonstrated that the capacitive sensor has great potential for applications in HSA detection.

頁(從 - 到)678-680
期刊Electronics Letters
出版狀態已出版 - 13 5月 2010


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