Development of an optofluidic SERS-based biomedical sensor

Brian Walton, Po Jung Huang, Jun Kameoka, Nicolaas Deutz, Gerard L. Coté

研究成果: 書貢獻/報告類型會議論文篇章同行評審

3 引文 斯高帕斯(Scopus)


Rapid assessment of radiation exposure to sensitive organs like the gut is extremely important for large populations exposed to ionized radiation, for instance during warfare. Recent results have shown that plasma citrulline levels appear to track gut function after irradiation levels in mice and humans. The current ways to monitor blood citrulline levels are bulky, laborious, time-consuming and expensive methods. Therefore, an optofludic point-of-care (POC) system using surface enhanced Raman spectroscopy to measure plasma citrulline as a marker for radiation exposure that overcomes the above issues is being developed. As a first step toward development of this system four colloidal nanoparticles, spherical gold, silver cubes, silica-gold nanoshells, and silver-gold nanocages have been analyzed for use in the POC system. Transmission electron microscopy (TEM) images have been taken of each nanoparticle to visualize the morphology of the nanoparticles, which is vital for SERS. Ultraviolet-visible (UV/Vis) spectroscopy was also collected to verify the extinction spectra for each nanoparticle was in resonance with the excitation wavelength. The nanoparticles were functionalized with mercaptobenzoic acid (MBA), a Raman reporter molecule, and SERS spectra were collected to determine which has better utility in a novel micro-to-nanochannel. The data showed that the silver nanocubes have a larger enhancement factor than the gold nanospheres, nanoshells, or nanocages. Currently, these nanocubes are being functionalized with the citulline for assessing the concentration sensitivity and dynamic range for ultimate use as a marker for radiation.

主出版物標題Optical Diagnostics and Sensing XVI
主出版物子標題Toward Point-of-Care Diagnostics
編輯Gerard L. Cote
出版狀態已出版 - 2016
事件Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics - San Francisco, United States
持續時間: 15 2月 201616 2月 2016


名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE


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國家/地區United States
城市San Francisco


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