Determination of Parabens by Injection-Port Derivatization Coupled with Gas-Chromatography-Mass Spectrometry and Matrix Solid Phase Dispersion

Rosalina Djatmika, Wang Hsien Ding, Hermin Sulistyarti

研究成果: 雜誌貢獻會議論文同行評審

6 引文 斯高帕斯(Scopus)

摘要

A rapid determination of four parabens preservatives (methyl paraben, ethyl paraben, propyl paraben, and butyl paraben) in marketed seafood is presented. Analytes were extracted and purified using matrix solid-phase dispersion (MSPD) method, followed by Injection port acylation gas chromatography-mass spectrometry (GC-MS) with acetic anhydride reagent. In this method, acylation of parabens was performed by acetic anhydride at GC injection-port generating reduction of the time-consuming sample-processing steps, and the amount of toxic reagents and solvents. The parameters affecting this method such as injection port temperature, purge-off time and acylation (acetic anhydride) volume were studied. In addition, the MSPD influence factors (including the amount of dispersant and clean-up co-sorbent, as well as the volume of elution solvent) were also investigated. After MSPD method and Injection port acylation applied, good linearity of analytes was achieved. The limits of quantitation (LOQs) were 0.2 to 1.0 ng/g (dry weight). Compared with offline derivatization commonly performed, injection port acylation employs a rapid, simple, low-cost and environmental-friendly derivatization process. The optimized method has been successfully applied for the analysis of parabens in four kind of marketed seafood. Preliminary results showed that the total concentrations of four selected parabens ranged from 16.7 to 44.7 ng/g (dry weight).

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文章編號012005
期刊IOP Conference Series: Materials Science and Engineering
299
發行號1
DOIs
出版狀態已出版 - 7 2月 2018
事件1st International Conference on Chemistry and Material Science, IC2MS 2017 - Malang, East Java, Indonesia
持續時間: 4 11月 20175 11月 2017

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