TY - GEN
T1 - Detecting the hybridization of circulating tumor DNA by nitride surface-enhanced Raman spectroscopy
AU - Nguyen, Thi Anh Nguyet
AU - Luo, Ching Lung
AU - Chien, Fan Ching
AU - Lai, Kun-Yu
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Intensive research efforts have been drawn on the development of biosensors for early cancer diagnosis. To achieve the goal, surface-enhanced Raman spectroscopy (SERS) is a promising tool in light of its excellent specificity and non-invasive nature [1,2]. However, SERS biosensors currently face two challenges: i) tedious surface functionalization; ii) signal fluctuation. To address these issues, we used Al nanoparticles to naturally immobilize DNA and InGaN quantum wells to stabilize the SERS signals via abundant surface charges [3]. These solutions significantly simplify the detection steps and render the sensitivity to the single-molecule level.
AB - Intensive research efforts have been drawn on the development of biosensors for early cancer diagnosis. To achieve the goal, surface-enhanced Raman spectroscopy (SERS) is a promising tool in light of its excellent specificity and non-invasive nature [1,2]. However, SERS biosensors currently face two challenges: i) tedious surface functionalization; ii) signal fluctuation. To address these issues, we used Al nanoparticles to naturally immobilize DNA and InGaN quantum wells to stabilize the SERS signals via abundant surface charges [3]. These solutions significantly simplify the detection steps and render the sensitivity to the single-molecule level.
UR - http://www.scopus.com/inward/record.url?scp=85175706649&partnerID=8YFLogxK
U2 - 10.1109/CLEO/EUROPE-EQEC57999.2023.10231688
DO - 10.1109/CLEO/EUROPE-EQEC57999.2023.10231688
M3 - 會議論文篇章
AN - SCOPUS:85175706649
T3 - 2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023
BT - 2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023
Y2 - 26 June 2023 through 30 June 2023
ER -
