Design and Development of a Novel Frozen-Form Additive Manufacturing System for Tissue Engineering Applications

Chao Yaug Liao, Wei Jen Wu, Cheng Tien Hsieh, Ching Shiow Tseng, Niann Tzyy Dai, Shan Hui Hsu

研究成果: 雜誌貢獻期刊論文同行評審

16 引文 斯高帕斯(Scopus)

摘要

High-quality scaffolds play a vital role in tissue engineering. The frozen-form method (FFM) (also known as low-temperature deposition manufacturing) can be used to fabricate scaffolds from biomedical polymers. These scaffolds may have both macroporous and microporous characteristics and may incorporate bioactive compounds or biomolecules during the process. In addition, scaffolds produced at low temperatures can prevent the occurrence of thermal hydrolysis, thereby improving the mechanical properties of scaffolds. In fabricating high-quality (without deformation and collapse) bioscaffolds through the FFM, the most crucial requirement is the creation of a uniform low-temperature environment. This study developed a frozen-form additive manufacturing system that includes a uniform cryogenic device to generate the uniform distribution of a low-temperature environment over a local region to produce large scaffolds that will not deform and collapse. A large square scaffold block and a high aspect ratio tubular scaffold were fabricated to verify the efficiency of this system. Furthermore, this study employed a selective compliance assembly robot arm to traverse two-dimensional deposition paths, unlike the conventional Cartesian gantry system. This study investigated the challenges stemming from the use of such a device for scaffold production and suggests methods for resolving such issues.

原文???core.languages.en_GB???
頁(從 - 到)217-225
頁數9
期刊3D Printing and Additive Manufacturing
3
發行號4
DOIs
出版狀態已出版 - 12月 2016

指紋

深入研究「Design and Development of a Novel Frozen-Form Additive Manufacturing System for Tissue Engineering Applications」主題。共同形成了獨特的指紋。

引用此