Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity

Chia I. Yen, Szu Mam Liu, Wei Shang Lo, Jhe Wei Wu, Yi Hsin Liu, Rong Jie Chein, Renqiang Yang, Kevin C.W. Wu, Jih Ru Hwu, Nianhan Ma, Fa Kuen Shieh

研究成果: 雜誌貢獻期刊論文同行評審

49 引文 斯高帕斯(Scopus)

摘要

Using a simple method, the aldehyde groups of zeolitic imidazolate framework-90 (ZIF-90) nanocrystals were converted into carboxyl, amino, and thiol groups, without affecting the integrity of the framework. Notably, for the first time, correlations between functionality and cytotoxicity are also demonstrated via in vitro cytotoxicity assays. The positive charged aminated-ZIF-90 presumably results in either perturbation of cell membrane, more efficient cell uptake, or both. Therefore, the half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity of about 30 μg mL-1. Supermodification: ZIF-90 (zeolitic imidazolate framework-90) nanocrystals were substituted with carboxyl, amino, and thiol groups without affecting framework integrity. In vitro cytotoxicity assays reveals that the positively charged aminated ZIF-90 presumably results in perturbation of cell membrane and/or more efficient cell uptake. The half-maximal effective (EC50) concentration of aminated-ZIF-90 has a higher cytotoxicity (ca. 30 μg mL-1).

原文???core.languages.en_GB???
頁(從 - 到)2925-2929
頁數5
期刊Chemistry - A European Journal
22
發行號9
DOIs
出版狀態已出版 - 24 2月 2016

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