Control of stem cell differentiation by using extrinsic photobiomodulation in conjunction with cell adhesion pattern

Saitong Muneekaew, Meng Jiy Wang, Szu yuan Chen

研究成果: 雜誌貢獻期刊論文同行評審

摘要

The induction and direction of stem cell differentiation into needed cell phenotypes is the central pillar of tissue engineering for repairing damaged tissues or organs. Conventionally, a special recipe of chemical factors is formulated to achieve this purpose for each specific target cell type. In this work, it is demonstrated that the combination of extrinsic photobiomodulation and collagen-covered microislands could be used to induce differentiation of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) with the differentiation direction dictated by the specific island topography without use of chemical factors. Both neurogenic differentiation and adipogenic differentiation could be attained with a rate surpassing that using chemical factors. Application of this method to other cell types is possible by utilizing microislands with a pattern tailored particularly for each specific cell type, rendering it a versatile modality for initiating and guiding stem cell differentiation.

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文章編號1812
期刊Scientific Reports
12
發行號1
DOIs
出版狀態已出版 - 12月 2022

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