Complex disease, gender and epigenetics

Zachary Kaminsky, Sun Chong Wang, Arturas Petronis

研究成果: 雜誌貢獻回顧評介論文同行評審

171 引文 斯高帕斯(Scopus)

摘要

Gender differences in susceptibility to complex disease such as asthma, diabetes, lupus, autism and major depression, among numerous other disorders, represent one of the hallmarks of non-Mendelian biology. It has been generally accepted that endocrinological differences are involved in the sexual dimorphism of complex disease; however, specific molecular mechanisms of such hormonal effects have not been elucidated yet. This paper will review evidence that sex hormone action may be mediated via gene-specific epigenetic modifications of DNA and histones. The epigenetic modifications can explain sex effects at DNA sequence polymorphisms and haplotypes identified in gender-stratified genetic linkage and association studies. Hormone-induced DNA methylation and histone modification changes at specific gene regulatory regions may increase or reduce the risk of a disease. The epigenetic interpretation of sexual dimorphism fits well into the epigenetic theory of complex disease, which argues for the primary pathogenic role of inherited and/or acquired epigenetic misregulation rather than DNA sequence variation. The new experimental strategies, especially the high throughput microarray-based epigenetic profiling, can be used for testing the epigenetic hypothesis of gender effects in complex diseases.

原文???core.languages.en_GB???
頁(從 - 到)530-544
頁數15
期刊Annals of Medicine
38
發行號8
DOIs
出版狀態已出版 - 12月 2006

指紋

深入研究「Complex disease, gender and epigenetics」主題。共同形成了獨特的指紋。

引用此