Coelectrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces

Wei Wen Hu, Hsing Ning Yu

研究成果: 雜誌貢獻期刊論文同行評審

53 引文 斯高帕斯(Scopus)


Chitosan and alginate are two frequently used biomaterials for tissue engineering. In this study, electrospinning technique was applied for their nanofiber fabrications to mimic extracellular environment (ECM). Polyethylene oxide (PEO) was applied to increase viscosities of polymer solutions to obtain nanofibers with appropriate morphologies. To modulate surface properties, a dual jet system was developed to coelectrospin chitosan and alginate nanofibers on one substrate. Because the deposition rates of electrospun fibers linearly correlated to the perfusion rates of polymer solutions, the composition ratios of nanofibers were thus manipulated, which determined both the chemical properties and hydrophobicity of fibrous mats. In vitro cell culture results suggested that the cell morphology highly depended on the fiber composition, and the composite nanofibers demonstrated higher biocompatibility than that on pure fibers. Finally, the degradation of alginate fibers was controlled by the crosslinking process. Reducing calcium ions resulted in partial fiber degradation, by which the composition ratios of nanofibers varied with time. This dynamically changed environment performed a promising property to improve viability of surface cells. Through this tunable system, surface properties of scaffolds can be finely adjusted to benefit tissue engineering applications.

頁(從 - 到)716-727
期刊Carbohydrate Polymers
出版狀態已出版 - 20 6月 2013


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