Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines

Lingtao Wang; Yi Jia Li; Anderson Lin; Shih Jui Chen; Mitchell Gross; Eun Sok Kim

Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines

Lingtao Wang, Yi Jia Li, Anderson Lin, Shih Jui Chen, Mitchell Gross, Eun Sok Kim

機械工程學系

研究成果: 書貢獻/報告類型 › 會議論文篇章 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

This paper reports recent development of micron-sized cell lysis without noticeable acoustic cavitation by a Self Focused Acoustic Transducer (SFAT). Localized cell lysis was obtained with prostate cancer cell lines and breast cancer cell lines by applying various power intensity levels at the transducer's fundamental and 3rd harmonic resonant frequencies (17.3 and 56 MHz, respectively). The cell lysis area was around 100 μm (fundamental) and 50 μm (third harmonic) in diameter. According to the results, the cell lysis area depended on the acoustic-wave frequency, but not on the applied acoustic intensity above the threshold intensity. Also, different cell lines showed varied sensitivity to focused acoustic energy, and had different energy threshold for localized cytolysis.

原文	???core.languages.en_GB???
主出版物標題	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
頁面	434-436
頁數	3
出版狀態	已出版 - 2011
事件	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States 持續時間: 2 10月 2011 → 6 10月 2011

出版系列

名字	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
卷	1

???event.eventtypes.event.conference???

???event.eventtypes.event.conference???	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
國家/地區	United States
城市	Seattle, WA
期間	2/10/11 → 6/10/11

UN SDG

此研究成果有助於以下永續發展目標

引用此

Wang, L., Li, Y. J., Lin, A., Chen, S. J., Gross, M., & Kim, E. S. (2011). Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines. 於 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (頁 434-436). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; 卷 1).

Wang, Lingtao ; Li, Yi Jia ; Lin, Anderson 等. / Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. 頁 434-436 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

@inproceedings{c8b9ad45d1534f3dbbaf88cc654a1a2e,

title = "Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines",

abstract = "This paper reports recent development of micron-sized cell lysis without noticeable acoustic cavitation by a Self Focused Acoustic Transducer (SFAT). Localized cell lysis was obtained with prostate cancer cell lines and breast cancer cell lines by applying various power intensity levels at the transducer's fundamental and 3rd harmonic resonant frequencies (17.3 and 56 MHz, respectively). The cell lysis area was around 100 μm (fundamental) and 50 μm (third harmonic) in diameter. According to the results, the cell lysis area depended on the acoustic-wave frequency, but not on the applied acoustic intensity above the threshold intensity. Also, different cell lines showed varied sensitivity to focused acoustic energy, and had different energy threshold for localized cytolysis.",

keywords = "Cancer, Localized cytolysis, Micro-electro-mechanical-system (MEMS), Self focused acoustic transducer (SFAT)",

author = "Lingtao Wang and Li, {Yi Jia} and Anderson Lin and Chen, {Shih Jui} and Mitchell Gross and Kim, {Eun Sok}",

year = "2011",

language = "???core.languages.en_GB???",

isbn = "9781618395955",

series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

pages = "434--436",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",

}

Wang, L, Li, YJ, Lin, A, Chen, SJ, Gross, M & Kim, ES 2011, Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines. 於 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 卷 1, 頁 434-436, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States, 2/10/11.

Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines. / Wang, Lingtao; Li, Yi Jia; Lin, Anderson 等.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 434-436 (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; 卷 1).

研究成果: 書貢獻/報告類型 › 會議論文篇章 › 同行評審

TY - GEN

T1 - Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines

AU - Wang, Lingtao

AU - Li, Yi Jia

AU - Lin, Anderson

AU - Chen, Shih Jui

AU - Gross, Mitchell

AU - Kim, Eun Sok

PY - 2011

Y1 - 2011

N2 - This paper reports recent development of micron-sized cell lysis without noticeable acoustic cavitation by a Self Focused Acoustic Transducer (SFAT). Localized cell lysis was obtained with prostate cancer cell lines and breast cancer cell lines by applying various power intensity levels at the transducer's fundamental and 3rd harmonic resonant frequencies (17.3 and 56 MHz, respectively). The cell lysis area was around 100 μm (fundamental) and 50 μm (third harmonic) in diameter. According to the results, the cell lysis area depended on the acoustic-wave frequency, but not on the applied acoustic intensity above the threshold intensity. Also, different cell lines showed varied sensitivity to focused acoustic energy, and had different energy threshold for localized cytolysis.

AB - This paper reports recent development of micron-sized cell lysis without noticeable acoustic cavitation by a Self Focused Acoustic Transducer (SFAT). Localized cell lysis was obtained with prostate cancer cell lines and breast cancer cell lines by applying various power intensity levels at the transducer's fundamental and 3rd harmonic resonant frequencies (17.3 and 56 MHz, respectively). The cell lysis area was around 100 μm (fundamental) and 50 μm (third harmonic) in diameter. According to the results, the cell lysis area depended on the acoustic-wave frequency, but not on the applied acoustic intensity above the threshold intensity. Also, different cell lines showed varied sensitivity to focused acoustic energy, and had different energy threshold for localized cytolysis.

KW - Cancer

KW - Localized cytolysis

KW - Micro-electro-mechanical-system (MEMS)

KW - Self focused acoustic transducer (SFAT)

UR - http://www.scopus.com/inward/record.url?scp=84883811653&partnerID=8YFLogxK

M3 - 會議論文篇章

AN - SCOPUS:84883811653

SN - 9781618395955

T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

SP - 434

EP - 436

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

Y2 - 2 October 2011 through 6 October 2011

ER -

Wang L, Li YJ, Lin A, Chen SJ, Gross M, Kim ES. Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines. 於 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. 2011. p. 434-436. (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011).

Cell lysis by low power focused acoustic transducer and investigation of acoustic intensity threshold for cytolysis of various cell lines

摘要

出版系列

???event.eventtypes.event.conference???

UN SDG

指紋

引用此