Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor

Sunita Keshari; Arun Balasubramaniam; Binderiya Myagmardoloonjin; Deron Raymond Herr; Indira Putri Negari; Chun Ming Huang

doi:10.3390/ijms20184477

Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor

Sunita Keshari, Arun Balasubramaniam, Binderiya Myagmardoloonjin, Deron Raymond Herr, Indira Putri Negari, Chun Ming Huang

生醫科學與工程學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

69 引文斯高帕斯（Scopus）

摘要

The glycerol fermentation of probiotic Staphylococcus epidermidis (S. epidermidis) in the skin microbiome produced butyric acid in vitro at concentrations in the millimolar range. The exposure of dorsal skin of mice to ultraviolet B (UVB) light provoked a significant increased production of pro-inflammatory interleukin (IL)-6 cytokine. Topical application of butyric acid alone or S. epidermidis with glycerol remarkably ameliorated the UVB-induced IL-6 production. In vivo knockdown of short-chain fatty acid receptor 2 (FFAR2) in mouse skin considerably blocked the probiotic effect of S. epidermidis on suppression of UVB-induced IL-6 production. These results demonstrate that butyric acid in the metabolites of fermenting skin probiotic bacteria mediates FFAR2 to modulate the production of pro-inflammatory cytokines induced by UVB.

原文	???core.languages.en_GB???
文章編號	4477
期刊	International Journal of Molecular Sciences
卷	20
發行號	18
DOIs	https://doi.org/10.3390/ijms20184477
出版狀態	已出版 - 2 9月 2019

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10.3390/ijms20184477

發酵皮膚微生物相之痤瘡貼膠
Huang, C.-M. (PI)
1/08/18 → 31/07/19
研究計畫: Research

引用此

Keshari, S., Balasubramaniam, A., Myagmardoloonjin, B., Herr, D. R., Negari, I. P., & Huang, C. M. (2019). Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor. International Journal of Molecular Sciences, 20(18), 文章 4477. https://doi.org/10.3390/ijms20184477

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title = "Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor",

abstract = "The glycerol fermentation of probiotic Staphylococcus epidermidis (S. epidermidis) in the skin microbiome produced butyric acid in vitro at concentrations in the millimolar range. The exposure of dorsal skin of mice to ultraviolet B (UVB) light provoked a significant increased production of pro-inflammatory interleukin (IL)-6 cytokine. Topical application of butyric acid alone or S. epidermidis with glycerol remarkably ameliorated the UVB-induced IL-6 production. In vivo knockdown of short-chain fatty acid receptor 2 (FFAR2) in mouse skin considerably blocked the probiotic effect of S. epidermidis on suppression of UVB-induced IL-6 production. These results demonstrate that butyric acid in the metabolites of fermenting skin probiotic bacteria mediates FFAR2 to modulate the production of pro-inflammatory cytokines induced by UVB.",

keywords = "Butyric acid, Microbiome, Probiotic, S. epidermidis, UVB",

author = "Sunita Keshari and Arun Balasubramaniam and Binderiya Myagmardoloonjin and Herr, {Deron Raymond} and Negari, {Indira Putri} and Huang, {Chun Ming}",

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year = "2019",

month = sep,

day = "2",

doi = "10.3390/ijms20184477",

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Keshari, S, Balasubramaniam, A, Myagmardoloonjin, B, Herr, DR, Negari, IP & Huang, CM 2019, 'Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor', International Journal of Molecular Sciences, 卷 20, 編號 18, 4477. https://doi.org/10.3390/ijms20184477

Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor. / Keshari, Sunita; Balasubramaniam, Arun; Myagmardoloonjin, Binderiya 等.
於: International Journal of Molecular Sciences, 卷 20, 編號 18, 4477, 02.09.2019.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

TY - JOUR

T1 - Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor

AU - Keshari, Sunita

AU - Balasubramaniam, Arun

AU - Myagmardoloonjin, Binderiya

AU - Herr, Deron Raymond

AU - Negari, Indira Putri

AU - Huang, Chun Ming

PY - 2019/9/2

Y1 - 2019/9/2

N2 - The glycerol fermentation of probiotic Staphylococcus epidermidis (S. epidermidis) in the skin microbiome produced butyric acid in vitro at concentrations in the millimolar range. The exposure of dorsal skin of mice to ultraviolet B (UVB) light provoked a significant increased production of pro-inflammatory interleukin (IL)-6 cytokine. Topical application of butyric acid alone or S. epidermidis with glycerol remarkably ameliorated the UVB-induced IL-6 production. In vivo knockdown of short-chain fatty acid receptor 2 (FFAR2) in mouse skin considerably blocked the probiotic effect of S. epidermidis on suppression of UVB-induced IL-6 production. These results demonstrate that butyric acid in the metabolites of fermenting skin probiotic bacteria mediates FFAR2 to modulate the production of pro-inflammatory cytokines induced by UVB.

AB - The glycerol fermentation of probiotic Staphylococcus epidermidis (S. epidermidis) in the skin microbiome produced butyric acid in vitro at concentrations in the millimolar range. The exposure of dorsal skin of mice to ultraviolet B (UVB) light provoked a significant increased production of pro-inflammatory interleukin (IL)-6 cytokine. Topical application of butyric acid alone or S. epidermidis with glycerol remarkably ameliorated the UVB-induced IL-6 production. In vivo knockdown of short-chain fatty acid receptor 2 (FFAR2) in mouse skin considerably blocked the probiotic effect of S. epidermidis on suppression of UVB-induced IL-6 production. These results demonstrate that butyric acid in the metabolites of fermenting skin probiotic bacteria mediates FFAR2 to modulate the production of pro-inflammatory cytokines induced by UVB.

KW - Butyric acid

KW - Microbiome

KW - Probiotic

KW - S. epidermidis

KW - UVB

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U2 - 10.3390/ijms20184477

DO - 10.3390/ijms20184477

M3 - 期刊論文

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AN - SCOPUS:85072142222

SN - 1661-6596

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Butyric acid from probiotic staphylococcus epidermidis in the skin microbiome down-regulates the ultraviolet-induced pro-inflammatory IL-6 cytokine via short-chain fatty acid receptor

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發酵皮膚微生物相之痤瘡貼膠

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