Brønsted Acid-Promoted Benzannulation of o-Alkynylbenzaldehyde and Alkyne, and the Positive Effect of Propargyl Alcohol

Cheng Chun Chen, Tzu Hsuan Kuan, Wen Wei Yuan, Shih En Chen, Jui Chen Fu, Yang Xun Chen, Hui Hsu Gavin Tsai, Duen Ren Hou

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

Bromotrimethylsilane-promoted benzannulation of o-alkynylbenzaldehydes and alkynes to yield 1-naphthyl aryl ketones is reported. The reaction conditions are mild, metal-free, and do not require pretreatment/protection of the substrates. We found that aryl propargyl alcohols were very effective substrates for this reaction, compared with other alkynes. Studies on the reaction scope, monitoring the reaction progress by 1H NMR, and theoretical calculations suggest that isochromenylium (benzopyrilium) ion is the key reaction intermediate. (Figure presented.).

原文???core.languages.en_GB???
頁(從 - 到)4122-4134
頁數13
期刊Advanced Synthesis and Catalysis
364
發行號23
DOIs
出版狀態已出版 - 8 12月 2022

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